Endometriosis is a common disease (there are more than 1 million cases in the U.S. alone), which can affect any woman of childbearing age, since the first menstruation or menarche to menopause, but sometimes lasts until after the menopause.

The disease impairs quality of life of women with the disease, their relationships, family and even work. His symptoms characterizing mainly by what is known as the three Ds: Dysmenorrheal,
dyspareunia (painful intercourse) and more commonly, pelvic pain, especially in the lower abdomen, in the lower back and pelvis itself. There may also be hyper menorrhea or very abundant menstrual bleeding and even inter-menstrual.

For these women at once becomes difficult or impossible to become pregnant, and often have intestinal disorders including diarrhea, constipation, painful bowel movements or cramps. And feel tired.

Achieving determine the diagnosis for endometriosis is difficult, hence the need to perform one or more tests, including a pelvic ultrasound or MRI. Laparoscopy may be necessary to review the bodies inside and view any or entopic endometrial tissue outside the uterus. Laparoscopy shows the location and extent of endometrial lesions, which are then biopsies.

There is evidence that women with this disease are more likely than other women to suffer immune system disorders in which the body attacks its own tissues (autoimmune diseases) and that women with endometriosis are also more likely to suffer fatigue syndrome chronic fibromyalgia.

Endometriosis can not be cured by medicine. However, there are many treatments, each with advantages and disadvantages.

For women with mild symptoms may not need treatment other than pain medications or analgesics. According to doctors, if they wish to become pregnant (although it depends on the age and the amount of pain), the ideal is to maintain a test season (from 6 months to a year) having unprotected sex. If pregnancy does not occur, the chances are you need more treatment .Las they want no family can then be treated with hormones, which is effective when tumors are small. There are several options in this regard, including a combination of estrogen and progesterone, birth control pills, progesterone alone, and agonists of gonadotropin-releasing hormone.

Birth control pills control the growth of the endometrial and often decrease the amount of menstrual flow. These are contender two hormones, a progestin and an estrogen.

GnRH agonists (used daily nasal spray or injection applied as monthly or quarterly) prevent the body from making certain hormones to prevent menstruation. And without menstruation, the growth of endometriosis is reduced or halted. Side effects, however, are hot flashes, fatigue, insomnia, headache, depression, osteoporosis and vaginal dryness. Administration is recommended for about six months after that, resume menses and pregnancy could occur.

Usually, surgery is the best option for women with extensive endometriosis, or suffering great pain. Some are major and minor. With laparoscopy, for example, tumors are removed and the scar tissue or destroyed with intense heat and close the blood vessels without stitches. The idea is to treat the endometriosis without harming healthy tissue around it. Recovery is rapid.

The latest resources for treating the disease are laparoscopy, major surgery that removes the endometriosis, and hysterectomy, which can be removed the uterus, ovaries and fallopian tubes. That yes, undergoing surgical procedures can not guarantee that the disease does not recur or that the pain is removed completely.

It is normal for the patient with endometriosis at first feel emotions like sadness, fear, anger, confusion or loneliness, and above all, uncertainty. Therefore it is important to get support from your partner, family and friends and learn all you can about the disease. Sometimes groups are useful for treatment and support will be essential to do relaxation exercises, particularly during periods of acute pain.

The main causes are a drop in estrogen levels in women during menopause and decreased testosterone in men. Women, especially those over 50, get osteoporosis more often than men.

Researchers estimate that about 20% of American women over age 50 have osteoporosis and 30% have osteopenia (low bone density abnormal) that may eventually lead to osteoporosis if not treated. From these figures, researchers estimate that 50% of women over age 50 will suffer a hip fracture, wrist, or vertebra (bones of the spine).

White women, especially those with a family history of osteoporosis, have a higher than average risk of developing the disease. Also, are identified as risk factors: cigarette smoking, the eating disorders, low body weight, low calcium diet, high alcohol consumption, early menopause, absence of menstrual periods (amenorrhea) and the use of certain medications such as steroids and anticonvulsants.

The treatment of all types of osteoporosis include calcium supplements and vitamin D, an exercise program appropriate for the patient, change in lifestyle to reduce risk factors and medications.

Medicines.

* Bisphosphonates: alendronate, risedronate, ibandronate
* Hormone replacement therapy: estrogen, estrogen-gestagen
* Tibolone
* Raloxifene
* Calcitonin
* Vitamin D, Vitamin D3 activates

Choosing a drug requires the patient characteristics, disease and our goals in the management of this disease. We can say that based on evidence based medicine there are some recommendations.

Bisphosphonates: These are first-line medicine in the treatment of postmenopausal osteoporosis prevention and treatment of steroid-induced osteoporosis and osteoporosis in men.

Hormone replacement therapy: first-line osteoporosis prevention and management of vasomotor symptoms associated with menopause. Second choice in the treatment of postmenopausal osteoporosis.

Calcitonin: second choice in the treatment of postmenopausal osteoporosis.

Calcium and vitamin D indicated in the prevention of osteoporosis

Monitoring Osteoporosis Treatment.

We have 2 parameters to evaluate the effectiveness of an osteoporosis treatment. The Bone Mineral Densitometry and markers of bone resumption.

Bone Densitometry.

It is easy to do a test that measures the amount of calcium that has a particular bone size, establishing whether this is normal, osteopenia or osteoporosis. We can measure different regions such as spine, hip, forearm, and calcaneus’s (heel) or total body. Indicates low bone mass increased risk of fracture. This procedure is used for diagnosis, but is useful in assessing people who have significant bone loss or to see the effectiveness of treatment. For this reason it requires a repeat at certain intervals (every 12 or 24 months).

The ideal in monitoring the treatment of osteoporosis is to have a Densitometry and the basic biochemical marker. The densitometry should be repeated 1 or 2 years after the first to observe the bone gain you could achieve with a medicine. Given that changes in bone densitometry are discrete (3-5%) is required to watch this time. Biochemical markers can repeat 2-3 months after starting treatment to inquire of the effectiveness of the drug used. An ideal response to treatment is the reduction of biochemical markers and increased bone mass, but arguably the goal of osteoporosis management is to reduce fracture risk and improve quality of life of the sufferer.

An announcement from the University of California Los Angeles (UCLA), United States, proposed the “Genetic Studies Program and Nutrition”, which aims to prepare researchers to be introduced in all aspects of obesity and diabetes.

Simin Liu, co-director of the program and professor of epidemiology and medicine at UCLA, said the academic project “includes aspects ranging from chemical biology to population analysis, thus give a broad and deep understanding of epidemics.

One reason that the initiative argues, is that obesity and diabetes – as a consequence of the first – is having a high incidence of most cardiovascular events, which have increased four times a diabetic cases.

Therefore, Liu believes that if these trends continue, the children born in the United States early this century, unless your parents live.

The program uses a holistic approach to the discipline of molecular epidemiology and field of metabolic diseases, and its mission is to get the best number of scientists, researchers and laboratory population to make a comprehensive study on the impact of genes and their interactions with behavior, nutrition and environment in disease epidemics.

Moreover, a recent study by UCLA documented that 21% of California teenagers, whose families are low income, are obese and unhealthy eating habits.

How can I prevent or delay diabetes?

* Lose weight if you are overweight or obese. Losing 10 to 20 pounds can help you significantly reduce your risk of heart disease, weight loss and helps reduce body fat, blood pressure and insulin resistance.

* Control your cholesterol. Eat a healthy diet low in saturated fat and cholesterol diet to keep blood cholesterol under 200 mg / dl.

* Control blood pressure. If you have diabetes, your blood pressure should be less than 130/80 mm Hg (millimeters of mercury) to reduce their risk of cardiovascular disease.

* Be physically active. Habitual physical activity and maintaining a healthy weight may help reduce your risk of developing type 2 diabetes. Exercise 30 minutes or more most days of the week. You can do 10 minute sessions several times a day. Walking is an excellent form of physical activity. Try walking for 10 minutes in the morning, at lunchtime and after work.

A note of Europe Press, mentions that a study by Cancer Center at Stony Brook University published in the online edition of the journal Lancet Oncology ’stresses that the cancer doubles the risk of bowel perforation.

The perforation in the stomach or intestines caused the death of more than 20 percent of cancer patients taking the medicine study and was more common in those suffering from advanced colorectal cancer and renal cancer.

Bevacizumab belongs to a class of medicine called angiogenesis inhibitors that slow the growth of tumors by cutting off its blood supply.

The medicine is beneficial in the treatment of many cancers including colorectal, renal cell cancer non-small cell lung and breast.

The researchers, led by Wu Shenshong, conducted a meta-analysis of 17 trials in which 12,294 involved patients with a variety of solid tumors to evaluate the role of bevacizumab in gastrointestinal perforation. The authors also examined whether the dose or have a specific type of cancer is associated with increased risk of perforation of the stomach or intestines.

The findings showed that the incidence of gastrointestinal perforation was 0.9 percent with a risk two times greater in patients receiving the medicine compared with controls, and a mortality of 21.7 percent in those who developed the perforation. The probability of occurrence of the disorder depended on the dose. Thus, smaller amounts of bavacizumab increased the risk of gastrointestinal perforation in 61 per cent (2.5 mg / kg per week) and increased by 167 percent (5 mg / kg per week).